6-sulfanyl-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride
6,7-dihydro-6-mercapto-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride
CAS: 153851-71-9
Molecular Formula: C5H8ClN3S
6-sulfanyl-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride - Names and Identifiers
6-sulfanyl-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride - Physico-chemical Properties
| Molecular Formula | C5H8ClN3S |
| Molar Mass | 177.66 |
| Melting Point | 127-128 °C (decomp) |
| Solubility | DMSO (Sparingly, Heated), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White Waxy |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
6-sulfanyl-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride - Reference Information
| overview | biapenem side chain is a pharmaceutical raw material and can be used to produce biapenem antibiotic drugs. Biapenem (Biapenem,LJC 10627) is a carbopillinene antibiotic for injection developed by Japan Lederle Company and American Cyanamide Company in 1989. Currently, Phase III clinical study has been completed in Japan and is awaiting approval for listing. The most notable feature of this product is 1 β-methyl carbapenem with bicyclic triazole at the 2-position S. Structure-activity relationship studies show that the presence of its side chain quaternary ammonium cation center is the key to affect the permeability of the outer membrane, making biapenem 2-4 times the activity of imipenem (Imipenem) in inhibiting Pseudomonas aeruginosa and anaerobic bacteria, and 4-8 times the activity of inhibiting drug-resistant Pseudomonas aeruginosa (Meropenem), which is more effective than ceftazidine in Acinetobacter and anaerobic bacteria. |
| reference quality standard | item standard appearance: white to yellowish crystalline powder content determination: 98% specific rotation:-26.0 to -36.0 pH: ph value should be 4.5~6.0 single impurity: |
| current situation of penm drugs in China | penm drugs are antibiotics with the widest antibacterial spectrum and strong antibacterial activity so far, so they play an important role in the last line of defense against clinical severe infection. In recent years, due to the severe problem of drug-resistant bacteria, the global and domestic use of this type of drug has increased rapidly. Imipenem-cilastatin, panipenem-betametron, Meropenem, Biapenem (biapenem side chain), ertapenem and doniepenem have been listed worldwide. However, the penem class is clinically used as a second-line drug. The government's guiding principles for the rational use of antibiotics and the high price also greatly limit the expansion of the number of penem used. These factors determine that this type of drug is still a kind of high value-added, small-scale "noble" variety in the short term. In 2008, the sales scale of Peinan terminals in the Chinese market was 1.89 billion yuan (equivalent to 0.278 billion US dollars), accounting for 9% of the total sales of nearly 3 billion US dollars in the world. Sales volume reached about 12.43 million. Consumption of raw materials 5~6 tons/year, of which domestic raw materials are 1.9 tons (including 1.8 tons of meropenem and 0.14 tons of imipenem), accounting for 36%. In the raw material export market, in 2008, China's three major products-meropenem, imipenem and intermediate 4-AA, their raw material exports were 6 tons, 1.3 tons and 40 tons respectively, accounting for more than 60% of the demand for raw materials in the global generic drug market. Since 2009, the international market demand has continued to grow, and the technical cost of Peinan raw materials and intermediates in my country has gradually gained advantages. In particular, Meropenem has a large share in the international market and has a certain price voice. 2009's annual exports of Meropenem and 4-AA are expected to reach 8 tons and 50 tons respectively, with a growth rate of about 30%. Peinan drugs will continue to grow rapidly and steadily at their own "pace. |
Last Update：2024-04-09 21:04:16
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Product Name: BIAPENEM SIDE CHAIN Request for quotationCAS: 153851-71-9
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Product Name: 6,7-dihydro-6-mercapto-5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride Visit Supplier Webpage Request for quotationCAS: 153851-71-9
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Product Name: 6,7-dihydro-6-mercapto-5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride Visit Supplier Webpage Request for quotationCAS: 153851-71-9
Tel: +86-18821248368
Email: Int06@meryer.com
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Multiple Specifications
Product Name: BIAPENEM SIDE CHAIN Request for quotationCAS: 153851-71-9
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Spot supply
Product Name: Biapenem side chain? Visit Supplier Webpage Request for quotationCAS: 153851-71-9
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: 6,7-dihydro-6-mercapto-5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride Visit Supplier Webpage Request for quotationCAS: 153851-71-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 6,7-dihydro-6-mercapto-5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride Visit Supplier Webpage Request for quotationCAS: 153851-71-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
6-sulfanyl-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride
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Methyl 6-(thien-2-yl)-4-(trifluoromethyl)-7-azaindole-2-carboxylate
1,3,8-Triazaspiro[4.5]decane-2,4-dione, 8-[4-(4-fluorophenyl)-4-oxobutyl]-3-methyl-1-(1-methylethyl)-
N-(9-{(1R,3R,4R,7S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-2,5-dioxa-bicyclo[2.2.1]hept-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide
2-Chloro-1-(difluoromethyl)-3,4-difluorobenzene
4,7,10,13,16-Pentaoxanonadec-18-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl]-
Spirostan, 3,3-dimethoxy-, (5α,20β,25R)- (9CI)
287730-69-2
Tetrabromoterephthalic acid dichloride
Methyl 6-(thien-2-yl)-4-(trifluoromethyl)-7-azaindole-2-carboxylate
1,3,8-Triazaspiro[4.5]decane-2,4-dione, 8-[4-(4-fluorophenyl)-4-oxobutyl]-3-methyl-1-(1-methylethyl)-
N-(9-{(1R,3R,4R,7S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-2,5-dioxa-bicyclo[2.2.1]hept-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide
2-Chloro-1-(difluoromethyl)-3,4-difluorobenzene
4,7,10,13,16-Pentaoxanonadec-18-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl]-
Spirostan, 3,3-dimethoxy-, (5α,20β,25R)- (9CI)
287730-69-2